Elucidation of the mechanism of cardiac hypofunction after myocardial infarction

An international collaborative research group comprised of Kiyotaka Tokuraku, Director of the Center for Creative Collaboration in Muroran Institute of Technology, Dr. Xuan Li of the Division of Cardiovascular Medicine at the Department of Medicine, University of Cambridge, et al. has elucidated that phosphorylation of microtubule-associated protein (MAP4) by microtubule-affinity-regulating kinase (MARK4) and subsequent detyrosination of microtubules are involved in cardiac hypofunction after myocardial infarction. In the future, it is expected that effective treatment methods for improving chronic heart failure after myocardial infarction will be established by advancing research targeting MARK4.

These findings were published in Nature on May 26 (responsible author: Dr. Xuan Li).

This study was conducted as an international collaborative research project between the University of Cambridge (UK), Tongji Medical College (China), Hanover Medical School (Germany), Qingdao University (China), the University of Leicester (UK), Southern University of Science and Technology (China), Muroran Institute of Technology (Japan) and the University of Paris (France).

*Please refer to the following for details of the research:

URL:https://www.nature.com/articles/s41586-021-03573-5